Papers

InsightRX-led papers

Hughes, J. H., Tong, D. M. H., Burns, V., Daly, B., Razavi, P., Boelens, J. J., Goswami, S., & Keizer, R. J. (2023). Clinical decision support for chemotherapy-induced neutropenia using a hybrid pharmacodynamic/machine learning model. CPT: Pharmacometrics & Systems Pharmacology. https://doi.org/10.1002/psp4.13019.

Hughes, J. H., Woo, K. H., Keizer, R. J. & Goswami, S. (2022). Clinical decision support for precision dosing: opportunities for enhanced equity and inclusion in healthcare. Clin Pharmacol Ther. https://doi.org/10.1002/cpt.2799

Hughes, J. H., Tong, D. M. H., Faldasz, J. D., Frymoyer, A., Keizer, R. J. (2022). Evaluation of Neonatal and Paediatric Vancomycin Pharmacokinetic Models and the Impact of Maturation and Serum Creatinine Covariates in a Large Multicentre Data Set. Clin Pharmacokinet. https://doi.org/10.1007/s40262-022-01185-4

Tong, D. M. H., Hughes, J. H., Keizer, R. J. (2022) Evaluating and Improving Neonatal Gentamicin Pharmacokinetic Models Using Aggregated Routine Clinical Care Data. Pharmaceutics. 14(10):2089. https://doi.org/10.3390/pharmaceutics14102089.

Hughes, J. H., & Keizer, R. J. (2021). A hybrid machine learning/pharmacokinetic approach outperforms maximum a posteriori Bayesian estimation by selectively flattening model priors. CPT: Pharmacometrics & Systems Pharmacology, 10(10), 1150–1160. https://doi.org/10.1002/psp4.12684

Tong, D. M. H., Hughes, J. H., & Keizer, R. J. (2021). Use of Age-Adjusted Serum Creatinine in a Vancomycin Pharmacokinetic Model Decreases Predictive Performance in Elderly Patients. Therapeutic Drug Monitoring, 43(1), 139–140. https://doi.org/10.1097/FTD.0000000000000819

Hughes, J. H., Tong, D. M. H., Lucas, S. S., Faldasz, J. D., Goswami, S., & Keizer, R. J. (2021). Continuous Learning in Model‐Informed Precision Dosing: A Case Study in Pediatric Dosing of Vancomycin. Clinical Pharmacology & Therapeutics, 109(1), 233–242. https://doi.org/10.1002/cpt.2088

Keizer, R. J., Dvergsten, E., Kolacevski, A., Black, A., Karovic, S., Goswami, S., & Maitland, M. L. (2020). Get Real: Integration of Real-World Data to Improve Patient Care. Clinical Pharmacology and Therapeutics, 107(4), 722–725. https://doi.org/10.1002/cpt.1784

Keizer, R. J., ter Heine, R., Frymoyer, A., Lesko, L. J., Mangat, R., & Goswami, S. (2018). Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities. CPT: Pharmacometrics & Systems Pharmacology, 7(12), 785–787. https://doi.org/10.1002/psp4.12353

External collaborations

de Klaver, P. A. G., Keizer, R. J., Ter Heine, R., Smits, L., Boekema, P. J., Kuntzel, I., Schaap, T., de Vries, A., Bloem, K., Rispens, T., Hoentjen, F., & Derijks, L. J. J. (2023). Early At-Home Measurement of Adalimumab Concentrations to Guide Anti-TNF Precision Dosing: A Pilot Study. European Journal of Drug Metabolism and Pharmacokinetics, 48(4), 377–385. https://doi.org/10.1007/s13318-023-00835-7

Brooks J. T. , Solans B. P. , Lu Y., Kharbanda S., Dvorak C. C. , Lalefar N. , Long S., Gupta A. O., Horn B., Lamba J. K., Huang L., Apsel-Winger B., Keizer R. J., Savic R., Long-Boyle J. (2022). Prospective Validation and Refinement of a Population Pharmacokinetic Model of Fludarabine in Children and Young Adults Undergoing Hematopoietic Cell Transplantation. Pharmaceutics. 14(11):2462. https://doi.org/10.3390/pharmaceutics14112462.

Francke, M. I., Hesselink, D. A., Andrews, L. M., Van Gelder, T., Keizer, R. J., & De Winter, B. C. M. (2022). Model-Based Tacrolimus Follow-Up Dosing in Adult Renal Transplant Recipients: A Simulation Trial. Therapeutic Drug Monitoring, Publish Ahead of Print. https://doi.org/10.1097/FTD.0000000000000979

Brooks, J. T., Keizer, R. J., Long-Boyle, J. R., Kharbanda, S., Dvorak, C. C., & Friend, B. D. (2021). Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation. Frontiers in Pharmacology, 12, 750672. https://doi.org/10.3389/fphar.2021.750672

Zwart, T. C., de Vries, A. P. J., Engbers, A. G. J., Dam, R. E., van der Boog, P. J. M., Swen, J. J., Keizer, R. J., Dalton, R. N., Guchelaar, H.-J., de Fijter, J. W., & Moes, D. J. A. R. (2021). Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting. Clinical Pharmacokinetics, 60(9), 1201–1215. https://doi.org/10.1007/s40262-021-00998-z

Martial, L. C., Biewenga, M., Ruijter, B. N., Keizer, R., Swen, J. J., Hoek, B., & Moes, D. J. A. R. (2021). Population pharmacokinetics and genetics of oral meltdose tacrolimus (Envarsus) in stable adult liver transplant recipients. British Journal of Clinical Pharmacology, 87(11), 4262–4272. https://doi.org/10.1111/bcp.14842

Apsel Winger, B., Shukla, P., Kharbanda, S., Keizer, R. J., Goswami, S., Cowan, M. J., Dvorak, C. C., & Long-Boyle, J. (2021). The Relationship Between Busulfan Exposure and Achievement of Sustained Donor Myeloid Chimerism in Patients with Non-Malignant Disorders. Transplantation and Cellular Therapy, 27(3), 258.e1-258.e6. https://doi.org/10.1016/j.jtct.2020.12.005

Fors, J., Strydom, N., Fox, W. S., Keizer, R. J., & Savic, R. M. (2020). Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis. PLOS Computational Biology, 16(8), e1008107. https://doi.org/10.1371/journal.pcbi.1008107

Zwart, T. C., Moes, D. J. A. R., van der Boog, P. J. M., van Erp, N. P., de Fijter, J. W., Guchelaar, H.-J., Keizer, R. J., & ter Heine, R. (2021). Model-Informed Precision Dosing of Everolimus: External Validation in Adult Renal Transplant Recipients. Clinical Pharmacokinetics, 60(2), 191–203. https://doi.org/10.1007/s40262-020-00925-8

Morrisette, T., Lodise, T. P., Scheetz, M. H., Goswami, S., Pogue, J. M., & Rybak, M. J. (2020). The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse. Infectious Diseases and Therapy, 9(3), 561–572. https://doi.org/10.1007/s40121-020-00325-2

Ter Heine, R., Keizer, R. J., van Steeg, K., Smolders, E. J., van Luin, M., Derijks, H. J., de Jager, C. P. C., Frenzel, T., & Brüggemann, R. (2020). Prospective validation of a model-informed precision dosing tool for vancomycin in intensive care patients. British Journal of Clinical Pharmacology, 86(12), 2497–2506. https://doi.org/10.1111/bcp.14360

Frymoyer, A., Schwenk, H. T., Zorn, Y., Bio, L., Moss, J. D., Chasmawala, B., Faulkenberry, J., Goswami, S., Keizer, R. J., & Ghaskari, S. (2020). Model-Informed Precision Dosing of Vancomycin in Hospitalized Children: Implementation and Adoption at an Academic Children’s Hospital. Frontiers in Pharmacology, 11, 551. https://doi.org/10.3389/fphar.2020.00551

Shukla, P., Goswami, S., Keizer, R. J., Winger, B. A., Kharbanda, S., Dvorak, C. C., & Long-Boyle, J. (2020). Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population. Frontiers in Pharmacology, 11. https://www.frontiersin.org/articles/10.3389/fphar.2020.00888

Yu, C. Z., Myers, S. R., & Faldasz, J. D. (2020). Simulated Comparison of a Bayesian Clinical Decision Support System Versus Standard of Care For Achieving Gentamicin Pharmacokinetic Targets in Neonates. The Pediatric Infectious Disease Journal, 39(4), 313–317. https://doi.org/10.1097/INF.0000000000002592

Hughes, D. M., Goswami, S., Keizer, R. J., Hughes, M.-S. A., & Faldasz, J. D. (2020). Bayesian clinical decision support-guided versus clinician-guided vancomycin dosing in attainment of targeted pharmacokinetic parameters in a paediatric population. The Journal of Antimicrobial Chemotherapy, 75(2), 434–437. https://doi.org/10.1093/jac/dkz444

van Beek, S. W., Ter Heine, R., Keizer, R. J., Magis-Escurra, C., Aarnoutse, R. E., & Svensson, E. M. (2019). Personalized Tuberculosis Treatment Through Model-Informed Dosing of Rifampicin. Clinical Pharmacokinetics, 58(6), 815–826. https://doi.org/10.1007/s40262-018-00732-2

Frymoyer, A., Stockmann, C., Hersh, A. L., Goswami, S., & Keizer, R. J. (2019). Individualized Empiric Vancomycin Dosing in Neonates Using a Model-Based Approach. Journal of the Pediatric Infectious Diseases Society, 8(2), 97–104. https://doi.org/10.1093/jpids/pix109

Bartelink, I. H., Lalmohamed, A., van Reij, E. M. L., Dvorak, C. C., Savic, R. M., Zwaveling, J., Bredius, R. G. M., Egberts, A. C. G., Bierings, M., Kletzel, M., Shaw, P. J., Nath, C. E., Hempel, G., Ansari, M., Krajinovic, M., Théorêt, Y., Duval, M., Keizer, R. J., Bittencourt, H., … Boelens, J. J. (2016). Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. The Lancet Haematology, 3(11), e526–e536. https://doi.org/10.1016/S2352-3026(16)30114-4