R Packages

The InsightRX data science team maintains the following R packages:

• clinPK: Provides equations commonly used in clinical pharmacokinetics and clinical pharmacology, such as equations for dose individualization, compartmental pharmacokinetics, drug exposure, anthropomorphic calculations, clinical chemistry, and conversion of common clinical parameters.

• PKPDsim: Simulates dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation systems.

• PKPDposterior: Provides convenience functions around Stan, Torsten, and PKPDsim. The goal of the package is to make it easier to perform full-Bayesian inference in the context of model-informed precision dosing.

Install clinPK and PKPDsim from CRAN. PKPDposterior is not yet on CRAN, but you can install it from GitHub after first installing Torsten.

install.packages("clinPK")
install.packages("PKPDsim")
remotes::install_github("InsightRX/PKPDposterior")